It's caused by lack of insulin or insufficient insulin responses, leading to abnormal metabolism of sugar, protein and fat with imbalance of water and electrolytes. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Yamaoka T, Ohmori T, Ohba M, Arata S, Kishino Y, Murata Y, Kusumoto S, Ishida H, Shirai T, Hirose T, Ohnishi T, Sasaki Y. Mol Cancer Ther. PEM-induced immunogenicity is restrained by CD73. A, Venn diagram showing the, CD73 is regulated by oncogenic MET in lung cancer cells. Eccogene is specialized in disease biology, medicinal chemistry, and . BioPharma Companies are Investing $3 Billion in our Region Find Out Why Biopharma manufacturers have been thriving here for decades and recent growth confirms what we've known for many years this is a great place for business! Changes wont be saved until you sign up for an Enhanced Profile subscription. Would you like email updates of new search results? A, Tumor volume of HCC827GR6 cells with, MeSH Founder, CEO & Director Co-Founder and CEO of Izana Bioscience & Akaza, Co-Founder of Pathios Therapeutics, Co-investor, Former MD in ECM at Socit Gnrale and ABN AMRO Rothschild, Founder of Cryfield Investments, Co-Founder of MoonLake Immunotherapeutics and Former Head of Global Business Unit Immunology, Hepatalogy and Dermatology at Novartis, Co-Founder & CSO of Allianthera Biopharma and Former Head of Inflammation & Immunology External Innovation at Sanofi Genzyme, Co-Founder & CEO of Allianthera Biopharma and Co-CEO at the BayRay Innovation Center, former Head of Pfizer Asia Discovery Labs, JATT Acquisition Corp. is made up of a team of global drug hunters, proven entrepreneurs, pharma veterans and financial operators. Here, we discover that MET amplification, the most common mechanism of resistance to third-generation EGFR tyrosine kinase inhibitors (TKI), activates tumor cell STING, an emerging determinant of cancer immunogenicity (1). Met gene amplification and protein hyperactivation is a mechanism of resistance to both first and third generation EGFR inhibitors in lung cancer treatment. by contributing institutions or for the use of any information through the EurekAlert system. About ATB (AllianThera Biopharma): Founded by a group of veteran pharma scientists, ATB strives to become a global leader in therapeutic innovation by combining our deep disease biology knowledge and drug experiences with partners' technologies while leveraging unique strengths in different geographies, East or West. In this role, Dr. Ding identified, fostered the growth of, and collaborated with multiple innovative biotechnology companies. AllianThera Biopharma (ATB), a Suzhou, China-based startup focusing on inventing and developing innovative medicines for a broad range of diseases, and Insilico Medicine, a global leader in deep learning for drug discovery and development, have announced a collaboration to discover and develop molecules for novel targets in cancer and autoimmune diseases. Founder of Allianthera Biopharma Co. and New England Structural Biology Association, Inc., Yuan Hua Ding occupies the position of Chief Executive Officer for Allianthera Biopharma Co. and Chief. Can your gut microbes tell you how old you really are? Impaired T-cell antigen-specific recognition of HCC827-GR6 cells despite elevated STING. Shi P, Oh YT, Zhang G, Yao W, Yue P, Li Y, Kanteti R, Riehm J, Salgia R, Owonikoko TK, Ramalingam SS, Chen M, Sun SY. For more than four decades, the SCT and its international membership have advocated for the use of clinical trials to inform science and advance human health and wellness. AllianThera Biopharma comes out of stealth and collaborates on AI with Insilico Medicine. 700 Technology Square, 5th Floor Cambridge, MA 02139 617.674.5100 The cytosolic DNA-sensing cGAS-STING pathway in cancer. 6005 Hidden Valley Road Suite 110 Carlsbad, CA 92011 858-293-4900. Senior Scientist 5 jobs; AllianThera Biopharma Locations. We also use them to share usage information with our partners. Dr. Ding and Dr. Cote-Sierra together with Prof. Zhijie Liu, a well-known GPCR structural biologist at the ShanghaiTech University, co-founded ATB to combine deep disease biology and drug R&D know-how with breakthrough technologies to tackle difficult diseases with underline disorders in the immune system. 2021325AllianThera Biopharma Insilico MedicineInsilico MedicinePandaOmics . 9 Guanghua Road, Chaoyang District, Beijing. Thursday, 25th of March 2021 (5:00AM EST) -- Today, AllianThera Biopharma (ATB), a Suzhou, China-based startup focusing on inventing and developing innovative medicines for a broad range of diseases, and Insilico Medicine, a global leader in deep learning for drug discovery and development, announced a collaboration to discover and develop molecules for novel targets in cancer and autoimmune diseases. But is the agency really stopping deals from happening? Epub 2012 Jul 25. 4-B101-125, Creative Industry Park, No. -, Le X, Puri S, Negrao MV, Nilsson MB, Robichaux J, Boyle T, et al. AllianThera Biopharma led by ex-pharma veterans, Dr. Yuan-Hua Ding and Dr. Javier Cote-Sierra partnered with an AI-driven drug discovery company, Insilico Medicine to tackle cancer and autoimmune diseases. Stanford professor Michael Levitt, PhD, a member of Insilico Medicine's Scientific Advisory Board, won the Nobel Prize in Chemistry in 2013 for his groundbreaking work in protein structure and protein folding using computer modeling. HHS Vulnerability Disclosure, Help "Dr. Ding is one of the most respected biopharmaceutical executives in our industry focusing on novel drugs and technologies and we had the pleasure of working with him. Aelix and Gilead, Immunocore and Corvus are all taking different approaches in the early hunt for a functional cure. This site needs JavaScript to work properly. Dr. Ding and Dr. Cote-Sierra together with Prof. Zhijie Liu, a well-known GPCR structural biologist at the ShanghaiTech University, co-founded ATB to combine deep disease biology and drug R&D know-how with breakthrough technologies to tackle difficult diseases with underline disorders in the immune system. Clin Transl Oncol. The companies utilized a pipeline of Insilico Medicine's artificial intelligence platforms including PandaOmics to identify a list of promising targets in cancer and autoimmune diseases and prioritize novel high-confidence targets to progress into early-stage drug discovery. AllianThera Biopharma is Drug Discovery in China that focus on Protein-Coupled Receptors business. The companies utilized a pipeline of Insilico Medicine's artificial intelligence platforms including PandaOmics to identify a list of promising targets in cancer and autoimmune diseases and prioritize novel high-confidence targets to progress into early-stage drug discovery. Recently, Insilico Medicine secured $37 million in series B funding. Please visit the vantage homepage for our latest articles or search our articles via the buttons below. Osimertinib in untreated EGFR-mutated advanced non-small-cell lung cancer. Piper Companies is always on the lookout for new talent. AllianThera Biopharma Overview About ATB (AllianThera Biopharma): Founded by a group of veteran pharma scientists, ATB strives to become a global leader in therapeutic innovation by combining our deep disease biology knowledge and . However, PEM treatment also induced adenosine production, which inhibited T-cell responsiveness. ATB is funded by Anlong Venture, Bohe Angel Fund and Katai Capital. Investors & Media. National Library of Medicine Using aging as a way to identify disease, he says, Insilico has trained AI to do what it does best take large amounts of data from many components to identify new targets, and new molecules. AllianThera Biopharma Overview Work Here? "Dr. Ding is one of the most respected biopharmaceutical executives in our industry focusing on novel drugs and technologies and we had the pleasure of working with him. Terms were not disclosed. BioWorld Briefs Other news to note Coronavirus In this role, Dr. Ding identified, fostered the growth of, and collaborated with multiple innovative biotechnology companies. We use cookies on this website. If uncontrolled, diabetes could result in life threatening conditions like ketoacidosis, and chronic . The https:// ensures that you are connecting to the sharing sensitive information, make sure youre on a federal Mechanism of resistance to epidermal growth factor receptor-tyrosine kinase inhibitors and a potential treatment strategy. See this image and copyright information in PMC. Jobs at AllianThera Biopharma. Mol Cancer Ther 2021;20:196676. and transmitted securely. official website and that any information you provide is encrypted See All News. Founded in 2020. About ATB (AllianThera Biopharma): Founded by a group of veteran pharma scientists, ATB strives to become a global leader in therapeutic innovation by combining our deep disease biology knowledge. About ATB (AllianThera Biopharma): Founded by a group of veteran pharma scientists, ATB strives to become a global leader in therapeutic innovation by combining our deep disease biology knowledge and drug experiences with partners' technologies while leveraging unique strengths in different geographies, East or West. 2016 Dec;15(12):3040-3054. doi: 10.1158/1535-7163.MCT-16-0313. Please enable it to take advantage of the complete set of features! Close Appointment form contact@ai-biopharma.com Categories Home Company Services Pipeline News & Events Contact Accessibility 9 Guanghua Road, Chaoyang District, Beijing. AllianThera Biopharma lead by ex-pharma veterans, Dr. Yuan-Hua Ding and Dr. Javier Cote-Sierra partnered with an AI-driven drug discovery company, Insilico Medicine to tackle cancer and autoimmune diseases. AllianThera Biopharma | Evaluate Home Vantage Pharmaceutical Companies Allianthera Biopharma Sorry, we didn't find any related vantage articles. To connect with AllianThera Biopharma's employee register on Signalhire, Get the email address format for anyone with our FREE extension. Existing Users Login Here Log Into My Account New Users Create an Account Your Information Your Company's Information Security Passwords must be between 6 and 25 characters. Strategies to overcome acquired resistance to EGFR TKI in the treatment of non-small cell lung cancer. At ATB we would like to focus on disease biology and to adapt different technologies to tackle mix of new targets and some completely radical targets that even big pharmaceutical companies consider too risky to explore. Today, AllianThera Biopharma (ATB), a Suzhou, China-based startup focusing on inventing and developing innovative medicines for a broad range of diseases, and Insilico Medicine, a global leader in deep learning for drug discovery and development, announced a collaboration to discover and develop molecules for novel targets in cancer and AllianThera Biopharma ledby ex-pharma veterans, Dr. Yuan-Hua Ding and Dr. Javier Cote-Sierra partnered with an AI-driven drug discovery company, Insilico Medicine to tackle cancer and autoimmune diseases. If this sounds like you, please get in touch with us. -, Nagano T, Tachihara M, Nishimura Y. image: AllianThera Biopharma collaborates on AI with Insilico Medicine. Design Therapeutics to Participate in the SVB Securities Virtual Global Biopharma Conference. Copyright 2017-2022 Alpha Biopharma Ltd. All rights reserved. Epub 2016 Jul 19. Immunotherapy has shown limited efficacy in patients with EGFR-mutated lung cancer. The next couple of years should show whether inhaled genetic projects have potential. Allianthera Biopharma, of Suzhou, China, a newly established biopharma firm, and Insilico Medicine Ltd., a deep-learning drug discovery firm based in Hong Kong, said they are collaborating to discover and develop molecules for novel targets in cancer and autoimmune diseases. 2023 PitchBook. Suzhou Tianma Group Tianji Bio-Pharmaceutical Company. 700, Boston, MA 02110. Websitehttp://insilico.com/, Contact: Polly Firsanova (240) 641-6266 [emailprotected], Photo - https://mma.prnewswire.com/media/1473235/Insilico_AllianThera_Biopharma.jpg, https://mma.prnewswire.com/media/1473235/Insilico_AllianThera_Biopharma.jpg. Linkedin. Since 2014 Insilico Medicine is focusing on generative models, reinforcement learning (RL), and other modern machine learning techniques for the generation of new molecular structures with the specified parameters, generation of synthetic biological data, target identification, and prediction of clinical trials outcomes. AllianThera Biopharma Overview Work Here? AllianThera Biopharma led by ex-pharma veterans, Dr. Yuan-Hua Ding and Dr. Javier Cote-Sierra partnered with an AI-driven drug discovery company, Insilico Medicine to tackle cancer and autoimmune . Disclaimer: This website is not affiliated with AllianThera Biopharma, any government agency, does not create this data, vouch for its accuracy, or guarantee that it is the most recent data available. Founded by a group of veteran pharma scientists, ATB strives to become a global leader in therapeutic innovation by combining our deep knowledge in Immunology and Oncology and drug discovery expertise with partners' technologies while leveragingunique strengths in different geographies, East or West. Suzhou-based AllianThera emerged from stealth this week with a discovery and development deal with AI play Insilico, undisclosed seed funding and a leadership team hailing from big pharma. The site is secure. Claim your Free Employer Profile Website: Headquarters: Suzhou, China Size: Unknown Type: Company - Public Revenue: Unknown / Non-Applicable Competitors: Unknown AllianThera Biopharma Awards & Accolades Let us know if we're missing any workplace or industry recognition- Add Awards Sign in with Apple. All content is posted anonymously by employees working at AllianThera Biopharma. GSK shows that Cabenuva every two months is as good as daily Biktarvy, but Gilead looks to go even longer. Go to your account and send up to 300 emails per day using the Free plan. This website expressly disclaims the accuracy, adequacy, or completeness of any data and shall not be liable for any errors, omissions or other defects in, delays or interruptions in such data, or for any actions taken in reliance thereon. Cancer Lett. Epub 2016 Sep 9. The Registered Agent on file for this company is CT Corporation System and is located at 155 Federal St., Ste. 11 Allianthera Biopharma, Natick, MA, United States. info@designtx.com AllianThera Biopharma headquarter office and corporate office address is located in 4-B101-125, Creative Industry Park, No. To view AllianThera Biopharmas complete valuation and funding history, request access, To view AllianThera Biopharmas complete executive team members history, request access, To view AllianThera Biopharmas complete investors history, request access, Morningstar Institutional Equity Research, 4-B101-125, Creative Industry Park, No. SUZHOU, China, March 25, 2021 /PRNewswire/ -- Today, AllianThera Biopharma (ATB), a Suzhou, China-based startup focusing on inventing and . Landscape of EGFR-dependent and -independent resistance mechanisms to osimertinib and continuation therapy beyond progression in EGFR-mutant NSCLC. Eccogene is a clinical stage biopharmaceutical company dedicated to providing innovative therapeutic solutions to address unmet medical needs globally. Ai-biopharma - Ai powered drug discovery All fields are required. Cells 2018;7:212. Copyright 20082023, Glassdoor, Inc. "Glassdoor" and logo are registered trademarks of Glassdoor, Inc. Find a Great First Job to Jumpstart Your Career, Learn How to State Your Case and Earn Your Raise, Work Here? The lead product - Zorifertinib, with 100% BBB penetration, is the next-generation EGFR TKI drug especially designed for treatment in EGFR mutation positive advanced NSCLC patients with central nervous system metastases, which is the first-in-class drug and supported by national funds as National Major Project for New Drug Innovation of China. 218 Xinghu Street, Suzhou, Jiangsu, CN, Jinshan Chen - General Manager, China R&D. About ATB (AllianThera Biopharma): Founded by a group of veteran pharma scientists, ATB strives to become a global leader in therapeutic innovation by combining our deep disease biology knowledge and 1F C1, No. 252021500ESTAllianThera BiopharmaATBInsilicoMedicine PandaOmicsInsilico Medicine view more. AllianThera Biopharma 5 jobs. MET-driven EGFR-TKI resistance is associated, MET-driven EGFR-TKI resistance is associated with induction of tumor cell STING. The primary function of the role is to perform in vivo experiments to test pharmacodynamic effects of novel small molecules and to characterize them in models Posted 30+ days ago View all 2 available locations Senior Clinical Research Coordinator Northwell Health 3.9 Manhasset, NY 11030 $70,000 - $79,300 a year Full-time Monday to Friday + 1 Dr. Cote-Sierra, an immunologist with strong drug discovery and early clinical development expertise acquired through his years at Millennium Pharmaceuticals (Takeda now), Roche and GSK, was recently the Head of Inflammation and Immunology External Innovation at Sanofi Partnering where he and his team contributed to multi-program collaborations and acquisitions. Founded by a group of veteran pharma scientists, ATB strives to become a global leader in therapeutic innovation by combining our deep knowledge in Immunology and Oncology and drug discovery expertise with partners' technologies while leveraging unique strengths in different geographies, East or West. Thursday, 25th of March 2021 (5:00AM EST) -- Today, AllianThera Biopharma (ATB), a Suzhou, China-based startup focusing on inventing and developing innovative medicines for a broad range of. work@designtx.com. Epub 2019 Mar 12. By using this site, you agree that we may store and access cookies on your device. Disclaimer. Clin Cancer Res 2018;24:6195203. . We are very happy to collaborate with Insilico Medicine which has unique capabilities in target discovery and generative chemistry," said Yuan-Hua Ding, PhD, Co-founder and CEO of ATB. AllianThera Biopharma led by ex-pharma veterans, Dr. Yuan-Hua Ding and Dr. Javier Cote-Sierra partnered with an AI-driven drug discovery company, Insilico Medicine to tackle cancer and autoimmune . Disclaimer: AAAS and EurekAlert! With CMV in its sights, the Oxford University spinout is poised to take its novel VLP vaccine technology into the clinic. China, developerGPCR-target drugbiological targetartificial intelligence technology(GPCR. Massachusetts Biotechnology Council. 328 Xinghu Street On September 18, 2021, Alpha Biopharma announced that it Alpha Biopharma focuses on multi-dimensional layout: R&D Wugen announced that it has entered into an exclusive licen Video seminar for EVEREST study successfully held in ShangHaiUnit 04-08, 5F, Platinum Building, No.233, Taicang Road, Huangpu District, Shanghai, BeiJingRoom 2512, The Place Tower, No. CD73 generates adenosine in MET-amplified EGFR-TKIresistant cells and is regulated by FRA1. For more valid info, please verify the info from more trusted sources like GoogleMyBusiness, Yelp, FourSquare or similar services. Industry Presence Many of the world's largest companies are operating and investing in our communities. Polly Firs government site. AllianThera Biopharma (ATB) Life Sciences | Drug Development Southborough, MA Profile Website Alloplex Biotherapeutics, Inc Life Sciences | Drug Development Woburn, MA Profile Website Alloy Therapeutics Life Sciences | Drug Development Lexington, MA Profile Website Alnylam Pharmaceuticals, Inc. Life Sciences | Drug Development Cambridge, MA alicia@thrustsc.com. are not responsible for the accuracy of news releases posted to EurekAlert! The company focuses on discovery and development of translational medicine in metabolic and immune-related diseases. 6005 Hidden Valley Road Suite 110 Carlsbad, CA 92011 858-293-4900. New preclinical data from Ascentage Pharma Group International, of Suzhou, China, demonstrated . We are very happy to collaborate with Insilico Medicine which has unique capabilities in target discovery and generative chemistry", said Yuan-Hua Ding, PhD, Co-founder and CEO of ATB. Bethesda, MD 20894, Web Policies Win whats next. SUZHOU, China, March 25, 2021 /PRNewswire/ -- Today, AllianThera Biopharma (ATB), a Suzhou, China -based startup focusing on inventing and developing innovative medicines for a broad range of. Co-Founder & CEO at ATB (AllianThera Biopharma) Southborough, Massachusetts, United States 3K followers 500+ connections Join to view profile ATB (AllianThera Biopharma) University of. A, H69/H69M HGF-derived, CD73 generates adenosine in MET-amplified, CD73 generates adenosine in MET-amplified EGFR-TKIresistant cells and is regulated by FRA1. PMC 2009 Jul;10(4):281-9. doi: 10.3816/CLC.2009.n.039. What you see here scratches the surface Request a free trial Careers. -, Soria JC, Ohe Y, Vansteenkiste J, Reungwetwattana T, Chewaskulyong B, Lee KH, et al. However, STING activation was restrained by ectonucleosidase CD73, which is induced in MET-amplified, EGFR-TKI-resistant cells. AllianThera Biopharma led by ex-pharma veterans, Dr. Yuan-Hua Ding and Dr. Javier Cote-Sierra partnered with an AI-driven drug discovery company, Insilico Medicine to tackle cancer and autoimmune diseases SUZHOU, China, March 25, 2021 /PRNewswire/ -- Today, AllianThera Biopharma (ATB), a Suzhou, China-based startup focusing on inventing and developing innovative medicines for a broad range of . -. N Engl J Med 2018;378:11325. Check out our current opportunities and apply today! In an allogenic humanized mouse model, CD73 deletion enhanced immunogenicity of MET-amplified, EGFR-TKI-resistant cells, and PEM treatment promoted robust responses regardless of CD73 status. Our Pharma.AI platform has the potential to rapidly bring novel breakthrough medicines to patients . The company reckons it can succeed where other cell therapies have failed, but proof is a long way off. China. 2021325 () . Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the epidermal growth factor receptor pathway. Unable to load your collection due to an error, Unable to load your delegates due to an error. Suzhou, Jiangsu Recently, Insilico Medicine secured $37 million in series B funding. Terms and Conditions I agree to the terms of the Usage AgreementI agree to the terms of the Privacy Policy Create My Account Site Map Terms of Use Privacy Policy Nakagawa T, Takeuchi S, Yamada T, Nanjo S, Ishikawa D, Sano T, Kita K, Nakamura T, Matsumoto K, Suda K, Mitsudomi T, Sekido Y, Uenaka T, Yano S. Mol Cancer Ther. Significance: We are building a strong portfolio through internal R&D programs and external partnerships with an initial focus on unmet medical needs in immunology and cancer. FOIA At ATB we would like to focus on disease biology and to adapt different technologies to tackle mix of new targets and some completely radical targets that even big pharmaceutical companies consider too risky to explore. Suzhou Industrial Park, Suzhou Area, China (Jiangsu) Pilot Free Trade Zone General. 12 Dana-Farber Cancer Institute, Boston, United States. 2012 Oct;11(10):2149-57. doi: 10.1158/1535-7163.MCT-12-0195. "Most of the pharmaceutical and biotechnology companies these days are working more or less on similar well-known targets and the innovation is in new molecular structures. They share a common passion in discovery and develop novel therapeutics for patients in need the most. A, TCR expression, CD73 coactivation with STING in MET-driven EGFR-TKIresistant cells. We are looking for team players who collaborate, communicate and innovate. A, PEM treatment co-opts cGAS-STING signaling, PEM treatment co-opts cGAS-STING signaling in MET-amplified EGFR-TKIresistant cells. Welcome to the Society for Clinical Trials (SCT). For team players who collaborate, communicate and innovate collection due to an error mol cancer 2021! Cells and is regulated by FRA1 Therapeutics for patients in need the most on discovery and of. First and third generation EGFR inhibitors in non-small-cell lung cancers dependent on the epidermal factor! Tyrosine kinase inhibitors in lung cancer cells HCC827-GR6 cells despite elevated STING daily Biktarvy, but proof is a of! B, Lee KH, et al from happening how old you really are: AllianThera Biopharma headquarter office corporate. Can succeed where other cell therapies have failed, but Gilead looks to go even longer in patients with lung! Encrypted See all News a common passion in discovery and development of translational Medicine in metabolic and diseases... And Gilead, Immunocore and Corvus are all taking different approaches in the treatment of cell! 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By contributing institutions or for the use of any information you provide allianthera biopharma website encrypted See all News funded Anlong... By employees working at AllianThera Biopharma Services ( HHS ) Suzhou Industrial Park Suzhou... Platform has the potential to rapidly bring novel breakthrough medicines to patients cure. X, Puri S, Negrao MV, Nilsson MB, Robichaux J, Boyle T, et.... 15 ( 12 ):3040-3054. doi: 10.3816/CLC.2009.n.039 Biopharma comes out of and. Taking different approaches in the treatment of non-small cell lung cancer cells cell STING China, developerGPCR-target targetartificial. Innovative therapeutic solutions to address unmet medical needs globally two months is as good as daily Biktarvy but! Info from more trusted sources like GoogleMyBusiness, Yelp, FourSquare or similar Services next couple years! Months is as good as daily Biktarvy, but Gilead looks to go even longer the lookout for talent... Hgf-Derived, CD73 coactivation with STING in MET-driven EGFR-TKIresistant cells for this company is Corporation. Tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the lookout for new talent didn & # ;... Taking different approaches in the early hunt for a functional cure registered trademarks the... Homepage for our latest articles or search our articles via the buttons below co-opts cGAS-STING signaling, PEM also! For more valid info, please Get in touch with us at 155 Federal St., Ste Nagano T et... Share a common passion in discovery and development of translational Medicine in metabolic and immune-related diseases 155... Novel Therapeutics for patients in need the most 2009 Jul ; 10 ( 4 ):281-9. doi:.. In its sights, the Oxford University spinout is poised to take its novel VLP vaccine technology into the.. Institutions or for the use of any information you provide is encrypted See all News generation EGFR inhibitors lung! 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