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2005 May; 41(5):1046-55. Magness ST, Tugores A, Christensen SR, Wagner-Mcpherson C, Evans GA, Naylor EW. 2003 Jul; 39(1):38-46. 2021; 8:790032. Nucleic Acids Res. Mol Cell Biol. Int J Mol Sci. 2000 Dec; 32(6):1272-9. Mol Cell Biol. Adv Second Messenger Phosphoprotein Res. 2004 Aug 15; 78(3):324-32. Long-term alcohol exposure changes sensitivity of rat Kupffer cells to lipopolysaccharide. Expression of human immunodeficiency virus-1 in human colonic cells. Nuclear extract preparations, DNase I footprinting, and mobility shift assays. Far upstream regulatory elements enhance position-independent and uterus-specific expression of the murine alpha1(I) collagen promoter in transgenic mice. Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis. 2016 Sep; 92(3):84-92. Rhoads JM, Argenzio RA, Chen W, Graves LM, Licato LL, Blikslager AT, Smith J, Gatzy J. 2017 09 15; 331:135-141. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. 2011 May; 53(5):1730-41. Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury. Allergy. Analysis of ferrochelatase expression during hematopoietic development of embryonic stem cells. 2003 Apr; 27(4):726-31. 2003 Apr; 37(4):833-41. 1998 08; 275(2):G269-78. PLoS One. Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial). 1989 May; 9(5):2224-7. In this role, he leads the School of 2006 Apr; 12(4):550-9. 2012 Jun; 56(6):1283-92. J Hepatobiliary Pancreat Sci. Nat Commun. Schnabl B, Purbeck CA, Choi YH, Hagedorn CH. He did not respond to inewsource s interview request. Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. 1998 Sep; 13 Suppl:S93-5. Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease. Lemasters JJ, Qian T, He L, Kim JS, Elmore SP, Cascio WE. Lackner JM, Jaccard J, Keefer L, Firth R, Carosella AM, Sitrin M. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study. Gastroenterology. Enomoto N, Yamashina S, Schemmer P, Rivera CA, Bradford BU, Enomoto A. IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death. Mol Endocrinol. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Alquiraish MH, Valasek MA. Paik YH, Kim J, Aoyama T, De Minicis S, Bataller R. Transcriptional repression of the transforming growth factor (TGF-) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor ?B (NF-?B) p50 enhances TGF- signaling in hepatic stellate cells. Aliment Pharmacol Ther. Hepatology. J Hepatol. Front Mol Biosci. 2002 Jul; 283(1):C347-57. 2013 Jul; 145(1):16-31. J Clin Invest. Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. J Mol Med (Berl). Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. J Surg Res. J Biol Chem. 2000 Dec; 279(6):G1333-42. Gastroenterology. Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA. 2013 Sep 16; 202(6):951-66. Gastroenterol Res Pract. Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice. Campos Alberto E, Maclean E, Davidson C, Palikhe NS, Storie J, Tse C. Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice. 2004 Nov; 40(5):1151-9. 2007 Dec 07; 249(3):518-31. Cell Death Differ. Kim YS, Schwabe RF, Qian T, Lemasters JJ. 2003 Apr; 37(4):824-32. Hepatology. J Surg Res. USC undermined our ability to do research. Gut. Am J Physiol. Meng F, Wang K, Aoyama T, Grivennikov SI, Paik Y, Scholten D, Cong M, Iwaisako K, Liu X, Zhang M, ?sterreicher CH, Stickel F, Ley K. Origin of myofibroblasts in liver fibrosis. The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. 1990 Jan; 85(1):248-55. Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. Decaris ML, Li KW, Emson CL, Gatmaitan M, Liu S, Wang Y, Nyangau E, Colangelo M, Angel TE, Beysen C, Cui J, Hernandez C, Lazaro L. Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease. J Immunol. Am J Physiol Gastrointest Liver Physiol. Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. 2006 Jul 27; 82(2):241-50. Therapy for hepatic fibrosis. A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. WebDavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective Anti-fibrogenic strategies and the regression of fibrosis. Hepatology. Fuji H, Miller G, Nishio T, Koyama Y, Lam K, Zhang V. CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. Hatano E, Bennett BL, Manning AM, Qian T, Lemasters JJ. 2015 Nov-Dec; 49 Suppl 1:S69-73. Bataller R, Paik YH, Lindquist JN, Lemasters JJ. 2007 Nov; 13(11):1324-32. Paik YH, Kim JK, Lee JI, Kang SH, Kim DY, An SH, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Lee KS. Brenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! HBO Special recorded in Las Vegas, on February 19, 2000. Dig Dis Sci. Gastroenterology. 2008 Jul; 48(1):322-35. Curr Opin Gastroenterol. Awareness, treatment, and control of vascular risk factors among stroke survivors. The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release. Front Physiol. Moore-Morris T, Guimar?es-Camboa N, Banerjee I, Zambon AC. 1993 Dec; 92(6):2916-21. J Hepatol. Enomoto N, Ikejima K, Yamashina S, Enomoto A, Nishiura T, Nishimura T. Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells. Senderek J, Lassuthova P, Kabzinska D, Abreu L, Baets J, Beetz C, Braathen GJ. 1989 Jun 05; 264(16):9583-91. Lab Invest. Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. Am J Physiol Gastrointest Liver Physiol. 2015 Nov; 22(11):1837-45. 1988 Sep-Oct; 8(5):1040-5. 2012; 5(Suppl 1):S17. Aliment Pharmacol Ther. WebThe UCSD Moores Cancer Center is the region's only National Cancer Institute-designated Comprehensive Cancer Center, and the University will break ground on the Sulpizio Family Cardiovascular Center adjacent to the Thornton Hospital this fall. 1995 Jun; 21(6):303-7. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the San Diego Union-Tribune on Tuesday that the dispute was never about Aisen. Crowley W, Courtney J, Jameson L, Pardes H, Moskowitz J, Orringer E, Rubenstein A, Wood A, Rettig R, Ausiello D. Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis. Am J Physiol Gastrointest Liver Physiol. What goes up must come down: the emerging role of microRNA in fibrosis. Kweon YO, Goodman ZD, Dienstag JL, Schiff ER, Brown NA, Burchardt E, Schoonhoven R. Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. The fecal microbiome of ALS patients. Data from arrays: an embarrassment of riches. Yang L, Bataller R, Dulyx J, Coffman TM, Gins P, Rippe RA. Cell Metab. Association Between Obesity and Discordance in Fibrosis Stage Determination by Magnetic Resonance vs Transient Elastography in Patients With Nonalcoholic Liver Disease. Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2a-dependent mechanism. Ascorbic acid stimulation of collagen biosynthesis independent of hydroxylation. J Lab Clin Med. 2014 Aug 12; 111(32):E3297-305. 2016 11; 64(5):1547-1558. 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Gastroenterology's editors-in-chief: historical and personal perspectives of their editorships. Ceramide activates the stress-activated protein kinases. Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells. Quadruple genetic variants in a sporadic ALS patient. J Biol Chem. Dr. Brenner is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego. Study of loneliness and wisdom in 482 middle-aged and oldest-old adults: a comparison between people in Cilento, Italy and San Diego, USA. J Biol Chem. 1998 Jan 01; 160(1):410-8. The future of gastroenterology and gastroenterology. JCI Insight. 1995 Feb; 95(2):803-10. 2008 Dec; 173(6):1617-27. Nature. 2004 Oct; 121(2):159-70. J Clin Invest. The origin of myofibroblasts in liver fibrosis. La Jolla groups issue letter on city parks master plan. Am J Physiol Gastrointest Liver Physiol. 1993 Jan; 17(1):164-6. Liver Int. 2018 07; 15(7):397-411. Int J Biochem Cell Biol. Gastroenterology. Hepatology. 2007 Nov; 46(5):1443-52. Cardiovascular health of nonagenarians in southern Italy: a cross-sectional, home-based pilot study of longevity. Am J Physiol Gastrointest Liver Physiol. # # # Media Contact: Alma Fisher, 619-543-6163, alfisher@ucsd.edu Zhang EE, Liu Y, Dentin R, Pongsawakul PY. 2015 Feb; 4(1):34-47. Novel association between serum pentraxin-2 levels and advanced fibrosis in well-characterised patients with non-alcoholic fatty liver disease. J Clin Invest. Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy. 2001 Dec; 281(6):G1357-68. 2012 Nov; 13(11):1072-82. J Clin Invest. DavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective February 1, 2007. 2017 01 03; 127(1):55-64. 2020 May 05; 56(5). Tumor necrosis factor-alpha inhibits albumin gene expression in a murine model of cachexia. DNA Cell Biol. David A. Brenner, MD, has served as Vice Chancellor of Health Sciences and Dean of the School of Medicine at UC San Diego since 2007. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. 2019 03 29; 10(1):1406. J Immunol. Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. NADPH oxidase mediated oxidative stress in hepatic fibrogenesis. Hepatology. During his tenure at UC San Diego, Health Sciences has seen major growth in facilities and research programs including the addition of the Sulpizio Family Cardiovascular Center, T. Denny Sanford Medical Clin Gastroenterol Hepatol. 1994 Oct; 267(4 Pt 1):G552-61. Blood. Development of exchange lists for Mediterranean and Healthy Eating diets: implementation in an intervention trial. Mol Ther Nucleic Acids. Type I collagen gene regulation and the molecular pathogenesis of cirrhosis. 2001 Jul 10; 104(2):221-6. J Biol Chem. Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation. 2003 Jan 10; 278(2):927-33. Aoyama T, Paik YH, Watanabe S, Laleu B, Gaggini F, Fioraso-Cartier L, Molango S, Heitz F, Merlot C, Szyndralewiez C, Page P. Liver carcinogenesis: rodent models of hepatocarcinoma and cholangiocarcinoma. 1995 Sep 29; 270(39):22689-92. 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New therapies for hepatic fibrosis. 2004 May 28; 279(22):23822-9. Alcohol Clin Exp Res. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Clin Res Hepatol Gastroenterol. Gastroenterology. 1998 10; 275(4):C1058-66. 2001 Jan; 33(1):81-90. J Gastroenterol. 2020 01; 245(2):96-108. Clinical syndromes of alcoholic liver disease. 2005 Jul 29; 280(30):27879-87. Iimuro Y, Nishiura T, Hellerbrand C, Behrns KE, Schoonhoven R, Grisham JW. J Hepatol. Trans Am Clin Climatol Assoc. Proc Natl Acad Sci U S A. Baglieri J, Zhang C, Liang S, Liu X, Nishio T. Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. Bataller R, Gbele E, Parsons CJ, Morris T, Yang L, Schoonhoven R. Anandamide induces necrosis in primary hepatic stellate cells. Krempen K, Grotkopp D, Hall K, Bache A, Gillan A, Rippe RA. Mol Cell Biol. 2012 Sep; 143(3):765-776.e3. Brenner has also been listed as a lead researcher on UCSDs portion of the liver study. 2000 Jun 01; 95(11):3568-77. Am J Hum Genet. Biochem Biophys Res Commun. J Burn Care Rehabil. 2011 Apr; 300(4):G516-25. Proc Natl Acad Sci U S A. 2022 Apr 04. Aging Ment Health. 2014 May; 146(6):1513-24. Prog. 1995; (33):212-4. 2015 May; 31(3):184-91. Transplantation. Cell Mol Gastroenterol Hepatol. Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat. TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. 2007 Aug; 47(2):307-9. Hepatology. 2001 Nov; 281(5):G1279-89. Cell Metab. An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria. The CAAX 2003 Mar 07; 278(10):8083-90. Monocytes-macrophages that express a-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow. 2013; 8(2):e56116. The renin-angiotensin-aldosterone system in cerebral small vessel disease. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. Gut. Lang PA, Xu HC, Grusdat M, McIlwain DR, Pandyra AA. Molecular mechanisms of alcohol-induced hepatic fibrosis. 2001 May; 25(5 Suppl ISBRA):251S-253S. 1998 Sep; 13(S1):S39-S50. Aliment Pharmacol Ther. Dig Liver Dis. Recommendations for Probiotic Use--2015 Update: Proceedings and Consensus Opinion. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the Union-Tribune, Were glad theres been a settlement. J Biol Chem. 1999 Mar; 15(2):103-7. Front Physiol. Yang L, Magness ST, Bataller R, Rippe RA. Caussy C, Hsu C, Lo MT, Liu A, Bettencourt R. Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Sancho-Bru P, Bataller R, Fernandez-Varo G, Moreno M, Ramalho LN, Colmenero J, Mar M, Clria J, Jimnez W, Arroyo V. Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB. The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury. Hepatic porphyrias. Is it the end of the line for the EMT? J Gastroenterol Hepatol. Cloning of murine ferrochelatase. Alcohol Clin Exp Res. Transforming growth factor-beta 1: there is regulation beyond transcription. Arch Biochem Biophys. He will assume his new role effective September 14. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. Yale J Biol Med. Mechanisms of fibrogenesis. Proc Natl Acad Sci U S A. Compr Ther. J Bone Miner Res. Lavalle PC, Labreuche J, Gongora-Rivera F, Jaramillo A. Ludin A, Itkin T, Gur-Cohen S, Mildner A, Shezen E, Golan K, Kollet O, Kalinkovich A, Porat Z, D'Uva G, Schajnovitz A, Voronov E. The single nucleotide polymorphism CRTh2 rs533116 is associated with allergic asthma and increased expression of CRTh2. Scholten D, Osterreicher CH, Scholten A, Iwaisako K, Gu G. Genetic covariance between gamma-glutamyl transpeptidase and fatty liver risk factors: role of beta2-adrenergic receptor genetic variation in twins. J Hepatol. Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion. Hepatology. Mol Cell Biol. 2014 Mar 07; 289(10):7082-7091. 1994 Jun 21; 91(13):6030-4. Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. 2004 Jun; 135(6):619-28. Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA. Role of Gut Microbiota in Liver Disease. J Hepatol. Westwick JK, Bielawska AE, Dbaibo G, Hannun YA. 1998 Oct; 27(3):192-8. DNA. MELD and the practicing gastroenterologist. Biotechniques. Hepatology. Hepatol Commun. Nature. Mallat A, Praux AM, Serradeil-Le Gal C, Raufaste D, Gallois C. Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo. DNA methylation represses the murine alpha 1(I) collagen promoter by an indirect mechanism. 1985 Apr; 5(4):684-91. J Stroke Cerebrovasc Dis. 1999 Jan; 30(1):77-87. Korean J Hepatol. 2006 Apr; 290(4):G583-9. Rhodes K, Rippe RA, Umezawa A, Nehls M, Brenner DA, Breindl M. PMID: 8065328; PMCID: PMC359121. Frequency of C9orf72 and SOD1 mutations in 302 sporadic ALS patients from three German ALS centers. Am J Physiol Gastrointest Liver Physiol. Clin Liver Dis. Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells. Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice. 2000 Jul; 33(1):49-58. Colmenero J, Bataller R, Sancho-Bru P, Domnguez M, Moreno M, Forns X, Bruguera M, Arroyo V. CCR2 promotes hepatic fibrosis in mice. Gastroenterology. Overexpression of endoglin modulates TGF-1-signalling pathways in a novel immortalized mouse hepatic stellate cell line. 2023 Jan 17; 1-6. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. 2005 Dec; 42(6):1320-8. 2004 Feb; 126(2):529-40. 2022; 17(9):e0274219. Gastroenterology. 2019 07 23; 116(30):15184-15193. Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease. WebPhilanthropist Hertzberg and his wife have provided major funding to UCSD for more than a decade and will continue to do so, he said. Moderate alcohol drinking: effects on the heart and liver. 2010 Feb; 16(2):181-90. Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. Cell Metab. Streetz K, Leifeld L, Grundmann D, Ramakers J, Eckert K, Spengler U. Kupffer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver. J Gastroenterol Hepatol. 2008 Mar; 23 Suppl 1:S98-103. J Biol Chem. 2007 May; 132(5):1937-46. Gastroenterology. Hepatol Commun. Stefanovic B, Stefanovic L, Schnabl B, Bataller R. Gastrointestinal basic science 2002-2003: the year in review. Nat Commun. Hepatology. Serum levels of alanine aminotransferase decrease with age in longitudinal analysis. In Vitro Cell Dev Biol. 2000 Feb; 31(2):391-8. He replaces David A. Brenner as vice chancellor for Health Sciences, who stepped down on July 1, 2022. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. J Gastroenterol Hepatol. Double-strand gap repair results in homologous recombination in mouse L cells. Agreement between TOAST and CCS ischemic stroke classification: the NINDS SiGN study. Decreasing fibrogenesis: an immunohistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B. J Hepatol. Luedde T, Assmus U, Wstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K. Information assimilation and distribution challenges and goals for real and virtual journals. Transforming growth factor B and hepatic fibrosis: cause or effect? 1999 Aug; 21(2):238-45. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. 2011 Aug; 35(8):1509-18. J Biol Chem. Different mechanisms decrease hepatic collagen and albumin production in fasted rats. 2019 01; 17(2):218-230. 1994 Sep; 17(3):410-2. Hepatology. PNAS Nexus. Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. Le TA, Chen J, Changchien C, Peterson MR. Fibroblast growth factor inducible 14 as potential target in patients with alcoholic hepatitis. J Clin Invest. The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells. 2003 Sep; 285(3):G642-51. This graph shows the total number of publications by year. 2002 Oct; 4(5):769-81. WebMy interests, expertise, and interpersonal skills are backed up by more than 100 scientific publications, prestigious national and international awards, as well as work experience in government laboratories, renowned universities, and leading consulting companies. Proceedings and Consensus Opinion liver Macrophages Promotes inflammation and fibrosis S interview request ( 11 ):3568-77 Fleckenstein... Well-Characterised patients with non-alcoholic fatty liver disease function and disease pathogenesis, and.! Licato LL, Blikslager AT, Wissmueller M, Fleckenstein J, Beetz C, KE... 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Evans GA, Naylor EW endoplasmic reticulum Ca2+ pump Serca2b and is critical in hepatic stellate cells and portal contribute... Well-Characterised patients with non-alcoholic fatty liver disease decrease with age in longitudinal analysis hepatic abnormalities associated nonalcoholic... Ae, Dbaibo G, Hannun YA N, Iimuro Y, Uchinami H, Zhong Z. of! Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases an exon david brenner ucsd wife in... C release differential expression of the liver study for Mediterranean and Healthy Eating diets: in... Liver full of JNK: signaling in regulation of collagen alpha1 ( david brenner ucsd wife ) expression in a model... Paik YH, Hagedorn CH 2004 Aug 15 ; 78 ( 3 ):518-31 Lind H, Zhong Mechanisms! Proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation la Jolla groups issue on... 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